| 摘要: |
| [摘要] 病理性近视家系的致病基因之一LAMA1基因与层粘连蛋白有关，LAMA1基因编码层粘连蛋白的ɑ1链，其在维系层粘连蛋白结构和功能上起主要作用，层粘连蛋白在眼球巩膜中的表达与病理性近视的发展密切相关，本文就病理性近视和层粘连蛋白相关性研究进展进行综述。 |
| 关键词: 病理性近视 LAMA1基因 细胞外基质 层粘连蛋白 |
| DOI：10.11724/jdmu.2014.05.20 |
| 分类号: |
| 基金项目:基金项目：国家自然科学基金项目（81271041） |
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| Relationship between pathological myopia and laminin |
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TAO Jun, ZHANG Feng-ju
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Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital,Capital Medical University, Beijing 100730, China
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| Abstract: |
| [Abstract] LAMA1 (alpha subunit of laminin) is one of the candidate genes responsible for pathological myopia. It plays a major role in maintaining the structure and function of laminin protein. Expression of laminin in sclera of the eyeball is closely related to the development of pathological myopia. This article reviews the research progress of relationship between pathological myopia and laminin. |
| Key words: [Key words] pathological myopia LAMA1 gene extracellular matrix laminin |
