| 摘要: |
| 多肽药物因具有相对成本低，生物活性强，副作用小, 不蓄积中毒，作用靶点专一等特点而被人们广泛应用。但天然存在的多肽类药物含量较少、纯度较低，无法满足临床的需求。经研究发现，通过体外合成的多肽药物具有合成周期短、生产量大等优势，能够有效克服天然多肽药物的不足，对于推广多肽类药物的应用有重要意义。本文对多肽类药物体外合成方法进行综述，为其今后的发展和临床应用提供参考。 |
| 关键词: 多肽药物 体外合成 化学合成 基因重组 |
| DOI：10.11724/jdmu.2014.02.19 |
| 分类号: |
| 基金项目:基金项目：大连市科技计划项目（2011E12SF029） |
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| Recent research progress in the methods of in vitro synthesis of peptide drugs |
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LIN Long 1,2，JIANG Su-yun 1，TANG Xin-qiang 2,31,2,3
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1.Dalian Insitute for Food and Drug Control, Dalian 116021, China;2. College of Pharmacy, Dalian Medical University, Dalian 116044, China;3. Department of Pharmacy, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China
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| Abstract: |
| [Abstract] Peptide drugs have been widely used for the low cost, high biological activity, low side effects, no accumulation of toxic, target specificity and other s. However, the natural peptide drugs have low concentration and low purity; can not meet the requirement of clinical applications. Synthetic peptide drugs have the priority of short synthetic cycle and large production volume, which are important for the promotion of clinical application of peptide drugs. Consulting the relevant literatures, this article intends to review the drugs synthesis and provide a reference for future drug development and clinical application. |
| Key words: [Key words] peptide drugs in vitro synthesis chemical synthesis genetic recombinant |
