| 摘要: |
| IL-8是一种多源性趋化因子，由单核细胞、内皮细胞等多种细胞合成与释放。IL-8在结直肠癌患者体内表达增高，IL-8血清水平的提高有助于结直肠癌患者病情监测。IL-8通过多种途径增强结直肠癌的肿瘤干细胞样特性，促进结直肠癌的血管形成、增生与转移等生物学活性。本文对IL-8与结直肠癌之间的关系进行综述。 |
| 关键词: IL-8血清水平与基因 结直肠癌 生物学活性 |
| DOI：10.11724/jdmu.2014.01.24 |
| 分类号: |
| 基金项目: |
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| IL-8 and colorectal cancer |
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CHENG Hui 1, LI Fang 21,2
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1.Class of 2009, Dalian Medical University, Dalian 116044, China;2. Department of Immunology, Dalian Medical University, Dalian 116044, China
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| Abstract: |
| [Abstract] IL-8 expression increases in patients of colorectal cancer, and the serum level of IL-8 contributes to monitoring colorectal cancer. There also have been some studies investigating the relationship between IL-8 gene and colorectal cancer. IL-8 increases cancer stem cell characteristics through a variety of ways, such as promoting angiogenesis, proliferation, metastasis and other biological activities of colorectal cancer. These studies provide novel approaches for prevention and treatment of colorectal cancer. |
| Key words: [Key words] IL-8 serum level and IL-8 gene colorectal cancer biological activities |
