IgG类抗体在急性格林巴利综合征发病机制中的作用

1.Department of Seven-Year Clinical Medicine, China Medical University, Shenyang 110001,China; 2.Department of Neurology, Dalian Central Hospital Affiliated to Dalian Medical University, Dalian 116021,China

关键词:  格林巴利综合征  IgG类抗体  急性炎症性脱髓鞘性多发性神经病  急性运动轴索型神经炎  Miller Fisher 综合征

Key words:  guillain barre syndrome  IgG antibody  AIDP（acute inflammatory demyelinative polyradiculoneuropathy）  AMAN（acute motor axonal neuropathy）  MFS（Miller Fisher syndrome）

摘要:

格林巴利综合征（guillain barre syndrome，GBS）是一种神经系统疾病，病理特点为神经根发生不同程度的损伤。其确切发病机制尚不清楚，但普遍研究证明这是一类自身免疫性疾病。临床上以急性发病为主，根据受损部位的不同，可分为多种亚型。本文主要就在自身体液免疫中，IgG抗体攻击神经根表面髓鞘和轴索上的不同成分（如神经胶质蛋白，神经束蛋白和神经节苷脂），引起神经根发生传导阻滞等功能障碍，诱发急性格林巴利综合征不同亚型进行综述。

Abstract:

Guillain Barre syndrome （GBS） is a kind of nervous system disease, which is characterized by different extent of injuries on nerve roots. The exact etiopathogenisis is not clear. But most studies proved that GBS is a kind of autoimunne disease. Acute GBS is regarded as major symptom in clinical GBS. According to the injuring parts of nerve roots, Acute GBS is devided into different subtypes. This article mainly review that in humoral immune reaction, IgG antibodies can attack different constituents on myelin and axon (such as neuroglian, nerofascin and ganglioside),resulting in the disturbance of nerve conduction, inducing different subtypes of acute Guillain Barre.