| 摘要: |
| Tubedown-1是一种新发现的N-末端乙酰转移酶，是酵母菌NAT-1 氨基末端乙酰转移酶的同源异型体，编码一个大约69 kD大小的有乙酰转移酶活性的蛋白质。目前认为tubedown-1可能参与脉管系统发育的调控，并抑制缺氧及糖尿病视网膜新生血管形成，有望为眼科血管性疾病的治疗提供新的方法。 |
| 关键词: tubedown-1 乙酰转移酶 视网膜新生血管 |
| DOI：10.11724/jdmu.2013.03.19 |
| 分类号: |
| 基金项目:基金项目：辽宁省教育厅高等学校科研项目（L2010127） |
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| Progress of Tubedown-1 and ocular neovascular diseases |
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QIN Xiu-hong 1, FAN Song-tao 1, ZHANG Zhen-zhen 2, LU Jian-min 1, ZHANG Chen-xi 11,2
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1.Department of Ophthalmology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China;2. Department of Ophthalmology, Shanghai Jiaotong University Affiliated Shanghai First People's Hospital, Shanghai 200080, China
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| Abstract: |
| [Abstract] Tubedown-1 is a novel N-terminal acetyltransferase. It is homologous to the yeasr NAT-1 N-terminal acetyltransferase and encodes a novel protein of 69 kD associated with an acetyltransferase activity. So far it is believed the downregulation of tubedown-1 may be involved in regulating vascular system development and inhibiting retinal neovascularization associated with hypoxia and diabetes. It may become a new therapy for ocular diseases. |
| Key words: tubedown-1 acetyltransferase retinal neovascularization |
