86例帕金森病患者非运动症状的临床研究

Non-motor symptoms in 86 patients with Parkinson’s disease

关键词:  帕金森病  非运动症状  便秘  尿频尿急  不宁腿综合征

Key words:  Parkinson's disease  non-motor symptoms  constipation  urinary frequency and urgency  restless legs

摘要:

目的　探讨帕金森病（PD)患者非运动症状（NMS）的发生与分布情况及其可能的影响因素。　方法　对86例PD患者进行NMS问卷（NMS Quest）调查，统计各种NMS的发生率，并对发生率最高的3个症状与性别、病程、H-Y分级及临床分型进行统计学分析。　结果　全部PD患者中NMS的发生率为96.5%，以便秘、尿频尿急、不宁腿综合征（RLS）最常见。便秘症状男性与女性、病程≤5年与＞5年者、临床分型之间相比，差异有显著性意义（P<0.05）；尿频尿急症状男性与女性、病程≤5年与＞5年者之间相比，差异有显著性意义（P<0.05）；而3者的发生均随H-Y分级的增加而增加。　结论　PD患者NMS的发生率非常高，以便秘、尿频尿急和RLS最为常见。性别、病程及H-Y分级是影响便秘及尿频尿急的重要因素，随着PD病情进展，3者的发生率也大大提高。

Abstract:

[Abstract] Objective To discuss the incidence and the distribution of non-motor symptoms (NMS) in Parkinson’s disease (PD) and the possible impact factors.　Methods The NMS questionnaire（NMS Quest) was administered to 86 patients with PD, calculating the incidence of the varying NMS, the top 3 items of NMS were statistically analyzed with sex, course of disease, Hoehn-Yahr (H-Y) grade and clinical type. 　Results The total incidence rate of non-motor symptoms of Parkinson's disease was 96.5%, constipation, urinary frequency and urgency,restless legs(RLS) were the top 3 items of NMS.According to the incidence, there were significant different in constipation between man and woman, course ≤5 and ＞5years, rigidity and tremor type（P<0.05）, urinary frequency and urgency between man and woman, course ≤5 and＞5years（P<0.05）.And the incidence of these 3 symptoms are greatly increased with the H-Y grade rising. 　Conclusion NMS in PD are common, constipation, urinary frequency, urinary urgency, and RLS are the top 3 items of NMS. Among them, sex,course of disease and H-Y grade are the important factors, and with H-Y grade of PD rising, the incidence of them are increased.