| 摘要: |
| [目的] 探讨脑源性神经营养因子（BDNF）基因多态性与中国北方汉族人群中的散发性多发性硬化症的关联。[方法]经过HapMap和Haploview分析，选取tagSNP并通过PCR-RFLP方法，对50例非家族遗传性多发性硬化患者和50例健康对照者的BDNF基因多态性分型进行病例对照研究。[结果]中国北方汉族人群BDNF基因存在一个基因连锁区域，选取rs6265、rs2049046和rs962369三个SNP作为tagSNP。在病例对照研究中，tagSNP分析及rs6265与rs2049046间的Haploview分析，P均＞0.05。 [结论]脑源性神经营养因子基因多态性与散发性多发性硬化无明显关联。 |
| 关键词: BDNF 多发性硬化 基因多态性 |
| DOI：10.11724/jdmu.2012.05.16 |
| 分类号: |
| 基金项目: |
|
| Relationship between brain-deried neurotrophic factor gene polymorphism and sporadic multiple sclerosis |
|
JI Xiao-fei 1, DONG Hui-jie 21,2
|
|
1. Department of Neurology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China;2. Department of Cardiology, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027,China
|
| Abstract: |
| [Objective] To explore the relationship between brain-deried neurotrophic factor (BDNF) gene polymorphism in the Han population in north of China and sporadic multiple sclerosis. [Methods] The tagSNPs were selected by HapMap and Haploview. Fifty sporadic multiple sclerosis and 50 controls were analysis by PCR-RFLP. [Results] There was one block in BDNF gene polymorphism of Han population in north China. The rs6265，rs2049046 and rs962369 were selected as tagSNP. The tagSNP and Haploview analysis showed there is no significant association between the multiple sclerosis and controls (P>0.05). [Conclusion] There is no relationship between BDNF gene polymorphism and sporadic multiple sclerosis. |
| Key words: BDNF multiple sclerosis gene polymorphism |
