血清胱抑素C测定对妊娠期早期肾损害诊断的临床意义

Diagnosis valve of Cystatin C to the early renal damage of pregnant women

关键词:  胱抑素C  晚期妊娠  妊高症  尿微量白蛋白

Key words:  CysC  late pregnancy  pregnancy-induced hypertension syndrome  microalbuminuria

摘要:

[目的] 探讨血清胱抑素C（CysC）测定对妊娠期妇女早期肾损害诊断的临床意义。 [方法] 分别检测35例正常晚期妊娠妇女、24例妊高症妇女和40例健康对照未孕女性的血清CysC、尿素氮(BUN)、肌酐(CR)、尿酸(UA)及尿微量白蛋白（MA）。 [结果] 血清CysC水平在正常晚期妊娠组（1.29±0.16）mg/L和妊高症组（1.82±0.46）mg/L均明显高于健康对照组(0.73±0.11)mg/L，差异有显著性意义（P<0.05），且妊高症组与正常晚期妊娠组比较差异也具有显著性意义（P<0.05）。尿MA水平妊高症组（3.01±1.91）mg/dL显著高于健康对照组（1.66±1.37）mg/dL及正常晚期妊娠组（1.09±1.28）mg/dL（P<0.05)。BUN、CR及UA水平在3组间均无显著差别（P>0.05）。 [结论] 血清CysC水平的升高可能对诊断妊娠期高血压并发早期肾损害具有一定意义。

Abstract:

[Objective] To evalute the valve of CysC to diagnose the early renal damage of pregnant women. [Methods] The CysC, urea (BUN) , creatinine (CR), uric acid (UA) and microalbuminuria (MA) were detected in 35 normal late pregnancy women, 24 pregnancy-induced hypertension syndrome women and 40 healthy (normal control group). [Results] The CysC levels of normal late pregnancy group (1.29±0.16) mg/L and pregnancy-induced hypertension syndrome group (1.82±0.46)mg/L were significantly higher than that of normal control group (0.73±0.11) mg/L (P<0.05). And pregnancy-induced hypertension syndrome group was significantly higher than that of normal late pregnancy group (P<0.05). The levels of MA had no statistical difference between normal late pregnancy group (1.09±1.28)mg/dL and normal control group (1.66±1.37)mg/dL (P>0.05), while the level of pregnancy- induced hypertension syndrome group (3.01±1.91)mg/dL was significantly higher than both of them（P<0.05）.There is no statistical difference of BUN, CR, UA among three groups(P>0.05). [Conclusion] The increase of serum CysC level might be helpful to diagnose pregnancy early renal damage.