引用本文:宋 伟,高洪波,金从军,齐永明,谢慧梁,张晓勇,邵玉军.部分脾动脉栓塞治疗肝癌合并脾功能亢进的临床观察[J].大连医科大学学报,2012,34(4):368-371.
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部分脾动脉栓塞治疗肝癌合并脾功能亢进的临床观察
宋 伟,高洪波,金从军,齐永明,谢慧梁,张晓勇,邵玉军
中国核工业北京四O一医院 肿瘤科,北京 房山 102413
摘要:
[目的] 评价部分脾动脉栓塞(PSE)治疗原发性肝癌合并脾功能亢进的安全性及临床疗效。 [方法] 对55例原发性肝癌合并肝硬化、门静脉高压及脾功能亢进患者进行超选择性部分脾动脉栓塞治疗,脾栓塞量50%~70%。术后1周、2周和1个月复查血常规、肝功能,术后1个月进行CT复查。记录术后并发症情况。 [结果] 栓塞术后1周、2周和1个月化验外周血象,白细胞、血小板明显高于栓塞前,红细胞、血红蛋白无明显变化;术后1个月白细胞(5.32±1.48)×109/L,血小板(105.68±18.18)×109/L;肝功能指标AST、ALT、TBIL在术后1周显著升高,术后2周和1个月后与术前相比差异无显著性意义;所有患者无脾脓肿等严重并发症发生。 [结论] 部分脾动脉栓塞是治疗原发性肝癌合并脾功能亢进安全有效的方法,可明显提高患者的生活质量。
关键词:  脾功能亢进  脾动脉栓塞术  原发性肝癌
DOI:10.11724/jdmu.2012.04.14
分类号:
基金项目:
Clinical report of PSE in treating primary hepatocellular carcinoma with hypersplenism
SONG Wei, GAO Hong-bo, JIN Cong-jun, QI Yong-ming, XIE Hui-liang, ZHANG Xiao-yong, SHAO Yu-jun
Department of Oncology, 401 Hospital of China Nuclear Industry, Fangshan 102413, China
Abstract:
[Objective] To retrospectively evaluate clinical efficacy and safety of partial splenic embolization (PSE) in treating primary hepatocellular carcinoma with hypersplenism. [Methods] Fifty-five primary hepatic carcinoma patients with liver cirrhosis, portal hypertension and hypersplenism were treated with PSE, the area of embolization was 50%~70%. After one week, 2 weeks and a month to re-examination the blood routine, liver function, one month postoperatively for CT scan. Postoperative complications were recorded. [Results] After embolization 1 week, 2 weeks and a month as peripheral blood tests, white blood cells, platelets embolization was significantly higher than the former, the red blood cells, hemoglobin had no significant difference. After embolization a month the white blood cells (5.32±1.48)×109 /L, and platelets (105.68±18.18)×109 /L. After one week, liver functions on AST,ALT and TBIL were significantly increased, after two weeks and after a month,they had no significant difference compared with before PSE. No patient suffered from severe complication such as splenic abscess. [Conclusion] PSE is a safe and effective method to treat primary hepatocellular carcinoma with hypersplenism.
Key words:  hypersplenism  partial splenic embolization  hepatocellular carcinoma