胎膜早破胎膜中白细胞介素18的表达及其临床意义

Expression and clinical significance of interleukin-18 in premature rupture of membrane

关键词:  白细胞介素18  胎膜早破  免疫组织化学

Key words:  interleukin-18  premature rupture of membrane  immunohistochemistry

摘要:

[目的] 探讨白细胞介素18(interleukin-18,IL-18)作为诊断胎膜早破(premature rupture of membrane,PROM) 生物学标志的可能性。 [方法] 应用免疫组织化学SP法检测42例PROM患者及28例正常产孕妇胎膜的IL-18表达，并加以比较。 [结果] PROM胎膜中IL-18表达明显高于正常胎膜组织（P<0.05）。合并亚临床绒毛膜羊膜炎PROM胎膜组织的IL-18表达明显高于不合并绒毛膜羊膜炎组织（P<0.05）。IL-18的表达与胎膜早破时间无明显相关性。 [结论] IL-18作为一种细胞因子有可能成为PROM的预测性指标

Abstract:

[Objective] To detect expresson of interleukin-18 (IL-18) in the tissne with premature rupture of fetal membrane (PROM) and clinical pathological significance of the expression. [Methods] The expression of IL-18 was detected in 42 tissues with premature rupture of fetal membranes and 28 normal of fetal membrane tissues without by immunohistochemistry. [Results] The expression of IL-18 was significantly higher in premature rupture of membrane than that in normal (P<0.05),and the expression of the tissues in PROM with sub-clinical chorioamonitis was significantly higher than that without (P<0.05). The correlativity between the expression of IL-8 and the time of PROM was not clear (P>0.05). [Conclusions] The IL-18 could become a predictable index of PROM.