乳腺癌干细胞耐放射性与细胞周期的关系

Relationship between radioresistance of breast cancer stem cell and cell cycle

关键词:  乳腺癌  干细胞  耐放射性  细胞周期

Key words:  breast cancer  stem cell  radiation resistance  cell cycle

摘要:

肿瘤的放射疗法是一种建立在细胞周期基础上的治疗方法，乳腺癌干细胞在放疗过程中出现的G2/M期阻滞、衰老途径下调、APE1水平升高及细胞周期调控相关基因p21和p53活性等改变直接或间接导致细胞周期紊乱，均与乳腺癌干细胞的耐放射性密切相关，是分子遗传学和肿瘤生物学研究的热点。

Abstract:

Radiative therapy of carcinoma is founded at the basis of cell cycle theory. The changes of breast cancer stem cell during radiation which include G2/M phase arrest, the senescence evasion, an elevated level of APE1 and alternation of cell cycle regulation related genes p21/p53, directly or indirectly cause the abnormal proliferation of cancer stem cells. These fundamental studies may result in broad applications within many different fields and may, in the long term, open a new path for cancer therapy.