| 摘要: |
| 脂联素(adiponectin，APN)是一种具有广泛生物学效应的脂肪细胞因子。最新研究从机制上肯定了脂联素促进胆固醇代谢、减轻炎症反应、改善内皮细胞功能、减少心肌细胞凋亡等作用，从而影响冠心病的发生发展过程。本文主要就脂联素对冠心病的保护作用及其机制的研究进展作一综述。 |
| 关键词: 脂联素 冠心病 动脉粥样硬化 |
| DOI：10.11724/jdmu.2012.03.23 |
| 分类号: |
| 基金项目:国家自然科学基金项目（30971065）；辽宁省教育厅基金项目（2009A194） |
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| Protection of Adiponectin on coronary heart disease and its mechanism |
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DENG Lin, LI Shu-zhuang
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Department of Physiology, Dalian Medical University, Dalian 116044, China
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| Abstract: |
| Adiponectin (APN) is one of the adipocytokines with a wide range of biological effects. New researches confirm the effection of adiponectin on promoting cholesterol metabolism, reducing inflammation, improving endothelial cell function, reducing myocardial apoptosis, and affecting the development of coronary heart disease. This article reviews the current knowledge about the protective effect of adiponectin in coronary heart disease and its mechanisms. |
| Key words: adiponectin coronary disease atherosclerosis |
