结直肠癌术后肝转移39例临床分析

Hepatic metastases of colorectal cancer post-operation: 39 cases report

关键词:  结直肠癌  肝转移  术后  化疗栓塞术

Key words:  colorectal cancer  hepatic metastasis  post-operation  chemoembolization

摘要:

[目的] 分析结直肠癌术后肝转移病例临床资料，以提高诊治水平和预防措施。[方法] 回顾性分析39例结直肠癌术后肝转移的病例临床资料，并比较不同治疗措施的疗效及肿瘤标记物水平。[结果] 手术联合肝动脉灌注化疗栓塞患者中位生存时间长（27个月），无治疗相关并发症。有32例患者的CEA水平较发生肝转移前或者原发肿瘤手术后都明显升高；有29例CA19-9升高。[结论] 肝转移灶外科切除联合肝动脉灌注化疗栓塞术是理想的治疗手段；介入化疗具有并发症少，全身影响小，疗效较好等优点；结直肠癌术后定期复查，尤其是CEA、CA19-9等指标，对早期诊断有一定价值。

Abstract:

[Objective] To improve the diagnosis and treatment liver metastasis colorectal cancer. [Methods] Thirty-nine cases suffering from hepatic metastases of colorectal cancer post-operation were analyzed retrospectively. Observed and compared curative effect of patients undergoing different therapeutic measures. [Results] The median survival time of patient undergoing surgical resection combined chemoembolization was the longest, 27 months (4-48 m), in addition, there was not complication. Tumor marker: CEA increased: 32 cases; CA19-9 increased: 29 cases. [Conclusion] Surgical resection combined chemoembolization is the best therapeutic measure. Compared to chemotherapy, the local and systemic complication of chemoembolization was less, and the effects turn out to be a good outcome. Regular follow-up plays an important role in preventing the hepatic metastasis of colorectal cancer. Especially, CEA, CA19-9 and other tumor markers has some value or was the key factor for early diagnosis.