| 摘要: |
| 线粒体DNA的突变和蛋白表达谱的异常，将严重影响细胞的凋亡和能量代谢过程，这一变化可能是恶性肿瘤细胞代谢及功能异常的重要组成部分。蛋白质组学技术可以分析肿瘤细胞或组织在某一时间点内全蛋白的表达情况及活性，而基于亚细胞水平研究的线粒体蛋白质组学较传统蛋白质组学研究有更高的分辨率。线粒体蛋白质组的改变与多种肿瘤相关，随着亚细胞分离技术和蛋白质鉴定技术的发展，线粒体蛋白质组学在寻找新的肿瘤相关特性蛋白研究中显示出越来越重要的意义。 |
| 关键词: 肿瘤 线粒体 蛋白质组学 |
| DOI：10.11724/jdmu.2012.02.19 |
| 分类号: |
| 基金项目:国家863高技术研究发展计划项目(2006AA02A309) |
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| Advance of mitochondrial proteomics in cancer research |
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LING Sun-bin1, TANG Bo2, WANG Li-ming21,2
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1. Grade 2007, Department of Seven-year Curriculum, Dalian Medical University, Dalian116044, China;2. Department of General Surgery, the Second Affiliated Hospital of Dalian Medical University, Dalian116027，China
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| Abstract: |
| The mutational mitochondrial DNA and abnormally expressed mitochondrial proteins, inducing a severe impact on apoptosis and energy metabolism of cells, may serve as a significant composition of overall metabolic and functional disorder in malignant cells. Proteomics displayed the capability on analysis of entire proteins expression in certain period in cells or tissues. Furthermore, mitochondrial proteomics, focusing on phenotype on subcellular level, has higher resolution. Numbers of researches have shown the correlation between changes in mitochondrial proteome and tumors. Along with the progress of subcellular isolation and proteins identification technics, mitochondrial proteomics plays an increasingly significant role in finding cancer-related specific molecules. |
| Key words: tumor mitochondria proteomics |
