受体型酪氨酸激酶RON在乳腺癌侵袭及转移中的作用研究进展

Development in the role of receptor tyrosine kinase RON in invasion and metastasis of human breast cancer

关键词:  乳腺肿瘤  受体型酪氨酸激酶RON  侵袭  转移  靶向治疗

Key words:  breast neoplasms  receptor tyrosine kinase RON  neoplasm invasiveness  matastasis  targeted therapy

摘要:

受体型酪氨酸激酶RON是原癌基因c-MET家族的一员。本文在简介原癌基因RON的生物学特征的基础上，综述了RON在乳腺癌侵袭及转移中的作用的研究进展，包括RON在乳腺癌中的异常表达、RON变异体、RON促进细胞迁移、肿瘤细胞附着、肿瘤生长和血管生成作用以及其在溶骨性骨转移中的作用等。单克隆抗体、小分子抑制物和特异性siRNA等靶向RON的治疗方法在乳腺癌治疗中有一定的潜在价值。

Abstract:

The receptor tyrosine kinase RON belongs to the c-MET proto-oncogene family. In this review the biological characteristics of RON were briefly introduced. In recent years, more and more research results indicate that RON may take an important role in invasion and metastasis of human breast cancer by aberrant expression in breast cancer, RON variants, promoting tumor cell migration, cell adhesion, invasive growth, angiogenesis as well as proteolytic bone metastasis. Targeted therapeutics using specific monoclonal antibodies, small-molecule inhibitors or siRNA have potential value in the treatment of breast cancer.