P16INK4A 和生存素在宫颈鳞状细胞瘤样变和宫颈鳞癌中表达的临床意义

Clinic significance of P16INK4A and survivin expressions in cervical intraepithelial neoplasia and squamous carcinoma

关键词:  P16  生存素  宫颈癌  免疫组化

Key words:  p16  survivin  cervical cancer  immunohistochemistry

摘要:

［目的］探讨检测P16INK4A 和生存素预测宫颈上皮内瘤样变（CIN）和宫颈鳞癌（SCC）可行性。［方法］免疫组织化学方法检测P16INK4A 和生存素在129例CIN与72例SCC的表达。［结果］在CIN1、CIN2、CIN3与SCC，P16INK4A 表达率分别为25.0%、42.9%、85.8%与97.2%；P16INK4A 表达和CIN病变分级呈正相关；生存素表达率分别为56.7%、33.3%、67.5%与97.2%，在CIN3和SCC表达中差异有显著性意义 （P<0.05）。［结论］检测P16INK4A 和生存素有助于诊断CIN病变分期和SCC。

Abstract:

［Objective］To explore the possibility of detecting the P16INK4A and survivin to predict the cervical intraepithelial neoplasia (CIN) and squamous cell carcinoma (SCC).［Methods］The p16INK4A and survivin expressions in 129 cases of CIN and 72 cases of SCC were detected with immunohistochemistry.［Results］In CIN1,CIN2,CIN3 and SCC,the p16INK4A expression rates were 25.0%,42.9%, 85.8% and 97.2%,respectively.It was positive correlation between the grade of CIN and P16INK4A expression,while the survivin expression rates were 56.7%,33.3%,67.5% and 97.2%,respectively.The difference of survivin expression in CIN 3 and SCC was significant (P<0.05).［Conclusions］The detection of P16INK4A and survivin can be helpful to judge the grade of CIN and SCC.