引用本文:赵鲁笳,邢广莹,王美华,刘天卿.进展期胃癌P53蛋白和PCNA/cyclin的表达[J].大连医科大学学报,2011,33(3):220-223.
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进展期胃癌P53蛋白和PCNA/cyclin的表达
赵鲁笳, 邢广莹, 王美华, 刘天卿
大连市友谊医院 病理科,辽宁 大连 116001
摘要:
[目的]了解P53和增殖细胞核抗原(PCNA)在进展期胃癌表达的临床意义。[方法]应用免疫组织化学技术检测65例进展期胃癌P53蛋白和PCNA的表达状况,并将它们的表达强度与肿瘤分化程度进行对比分析。[结果]P53阳性检出率与肿瘤恶性程度无显著相关性(P>0.05),但其表达强度随着癌组织分化程度的降低而逐渐增强(21.43%、25.00%、32.26%)。PCNA阳性表达强度与癌组织分化程度呈显著负相关(P<0.05)。[结论]进展期胃癌中P53蛋白和PCNA的表达程度,可作为肿瘤恶性程度及预后的判断指标。
关键词:  胃癌  P53蛋白  PCNA  免疫组织化学
DOI:10.11724/jdmu.2011.03.05
分类号:R735.2
基金项目:
Expressions of P53 and cyclin/PCNA in advanced gastric carcinoma
ZHAO Lu-jia, XING Guang-ying, WANG Mei-hua, LIU Tian-qing
Department of pathology,Dalian Friendship Hospital,Dalian 116001,China
Abstract:
[Objective]To explore the clinical significance of mutant P53 protein(P53)and proliferating cell nuclear antigen (cyclin/PCNA) in advanced gastric carcinoma.[Methods]Expressions of P53 and cyclin/PCNA of advanced gastric carcinoma in 65 patients were detected with half-quantitive LSAB immunohistochemical method.The relationship between the expression intensity and histological grade was analyzed.[Results]No significant relation between the positive expression rate of P53 and the malignant degree of gastric carcinoma was found(P>0.05),but the P53 expression intensity increased with the increasing in the malignant grade of gastric carcinoma (21.43%、25.00%、32.26%).The cyclin/PCNA expression intensity was related with the malignant grade of the carcinoma (P<0.05).[Conclusion]The P53 and cyclin/PCNA expressions might be used as markers to indicate the malignancy and prognosis of advanced gastric carcinoma.
Key words:  gastric carcinoma  P53 protein  cyclin/PCNA  immunohistochemistry