| 摘要: |
| 骨形态发生蛋白（BMPs）是一类属于转化生长因子-β超家族的多功能生长因子，具有诱导骨、软骨组织再生的能力。BMPs通过信号传导通路，引起靶基因的转录和表达。BMPs的生物学活性受多个水平的调控。本文着重就BMPs的信号传导通路及相关负性调控的研究进行综述。 |
| 关键词: 骨形态发生蛋白 信号传导通路 骨形态发生蛋白拮抗因子 |
| DOI：10.11724/jdmu.2011.02.22 |
| 分类号:Q593 |
| 基金项目: |
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| Signal transduction and antagonists of bone morphogenetic proteins |
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LIANG Yuan, CHANG Xin
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Department of Stomatology,the Second Affiliated Hospital of Dalian Medical University,Dalian 116027,China
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| Abstract: |
| Bone morphogenetic proteins (BMPs) are multifunctional cytokines belonging to the transforming growth factor-β(TGF-β) super-family.BMPs play key roles on the regeneration of bone and cartilage.BMPs regulate the transcription and expression of target genes by BMPs signaling pathway.A variety of processes modulate BMP activity.This review will focus on the BMPs signal pathway and related negative regulation. |
| Key words: BMPs signaling pathway BMP antagonist |
