| 摘要: |
| 丹参酮ⅡA是从活血化瘀中药丹参中提取的脂溶性有效成分，具有多种药理活性。本文按消化系统、生殖系统、呼吸系统、血液系统等肿瘤细胞分类，总结了国内外最新研究成果，表明了丹参酮ⅡA具有显著抑制肿瘤细胞增殖、诱导肿瘤细胞分化与凋亡等作用，其作用机制可能与调节凋亡相关基因caspase-3、p53、bcl-2、bax、c-myc等有关。 |
| 关键词: 丹参酮ⅡA 凋亡 抗肿瘤 诱导分化 抑制增殖 |
| DOI：10.11724/jdmu.2010.06.24 |
| 分类号: |
| 基金项目: |
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| Progress in research on anticancer effect of Tanshinone ⅡA and its mechanisms both in vivo and in vitro |
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MA Hui, FAN Qing
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Department of Pharmacy,the Second Affiliated Hospital of Dalian Medical University,Dalian 116027,China
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| Abstract: |
| Tanshinone ⅡA is a derivative of phenanthrene-quinone isolated from Salvia miltiorrhiza BUNGE,which is a traditional herbal medicine with a variety of pharmacological activity.This article,according to cancers in digestive,genital,respiratory systems and hematological malignancy et al,presents an overview of the current research results.Tanshinone ⅡA possesses significant effects of proliferation inhibition,differentiation induction and apoptosis.Its mechanisms are thought as regulating the expression of genes related to caspase-3,p53,bcl-2,bax,c-myc. |
| Key words: Tanshinone ⅡA apoptosis anticancer differentiation induction proliferation inhibition |
