| 摘要: |
| ［目的］研究BRAF在前列腺癌组织中表达及其临床意义。［方法］采用免疫组织化学技术检测74例前列腺癌、39例前列腺增生组织的BRAF蛋白表达，并对其与临床病理因素的关系进行相关性分析。［结果］前列腺癌与增生组织BRAF蛋白表达阳性率分别为64.86%与10.26%，二者差异有显著性意义（P<0.05）。前列腺癌组中，中高分化病例与低分化病例BRAF蛋白表达阳性率分别为43.48%与74.51%，二者差异有显著性意义（P<0.05）；（A+B）期（无浸润转移）病例与（C+D）期（有浸润转移）病例BRAF蛋白表达阳性率分别为42.50%与91.18%，二者差异有显著性意义（P<0.05）；≤60岁病例与>60岁病例BRAF蛋白表达阳性率分别为59.52%与71.88%，二者差异无显著性意义（P>0.05）。［结论］在前列腺癌组织BRAF蛋白表达明显增高，且与组织的分化、肿瘤临床分期及发生发展相关，检测其表达可能会有助与诊断和预后判断。 |
| 关键词: 前列腺癌 免疫组化 BRAF |
| DOI：10.11724/jdmu.2010.06.09 |
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| Expression of BRAF in prostate carcinoma and its significance |
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WANG Hui1, HOU Rui1, YANG Guang1, XUE Wen-lin1, Lü Shen2
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1.Department of Ultrasonography,the First Affiliated Hospital of Dalian Medical University,Dalian 116011,China;2.Central Laboratory,the Second Affiliated Hospital,Dalian Medical University,Dalian 116027,China
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| Abstract: |
| ［Objective］To investigate the clinicopathological relations of BRAF expression in prostate cancer.［Methods］Immunohistochemistry was used to detect the expression of BRAF in 74 cases of prostate carcinoma,and 39 cases of benign prostate hyperplasia (BPH).［Results］The positive rate of BRAF in the prostate carcinoma (64.86%) was significantly higher than that of BPH (10.26%) (P<0.05).The expression of BRAF was correlated with grade and stage of prostate cancer (P<0.05),but not to age of onset (P>0.05).［Conclusion］The abnormal expression of BRAF may play a role in the tumorigenesis and progression of prostate carcinoma,detection of which may be helpful to diagnose the cancer and predict its prognosis. |
| Key words: prostate carcinoma immunohistochemistry BRAF |
