铜绿假单胞菌注射液辅助治疗恶性肿瘤的应用进展

Advances in application of Pseudomonas aeruginosa injection in adjuvant therapy for malignant tumor

关键词:  铜绿假单胞菌注射液  肿瘤  免疫

Key words:  Pseudomonas aeruginosa injection  tumor  immunity

摘要:

铜绿假单胞菌注射液的基础研究和临床应用均表明其具有较强免疫原性，不仅调整机体体液免疫，使机体产生不同菌属的高效价广谱抗体；同时也可全面调整机体细胞免疫，增强机体抗感染能力。配合手术后的放化疗治疗，可以降低术后感染的并发症及肿瘤复发率、增强放化疗效果，提高肿瘤患者的生存质量，在多种恶性肿瘤的临床治疗中被证实使用有效，且安全可靠，无明显毒副作用。现将铜绿假单胞菌注射液辅助治疗恶性肿瘤的现状做一综述。

Abstract:

The basic research and clinical application of Pseudomonas aeruginosa injection show its strong immunogenicity,which is embodied in the regulation of the humoral immunity of the organism for the purpose of enabling the organism to produce high-titer and broad-spectrum antibodies from different genera as well as the full regulation of the cellular immunity of the organism for the purpose of improving the antibacterial capability of the organism.With post-operative concurrent radiotherapy and chemotherapy,Pseudomonas aeruginosa injection can reduce post-operative complications and tumor recurrence rate,enhance the effect of concurrent radiotherapy and chemotherapy and improve the quality of life in tumor patients,which has proved to be effective,safe and reliable during the clinical therapy for many kinds of malignant tumor,without significant toxic or side effects.This paper summarized the present situation on the application of Pseudomonas aeruginosa injection in the adjuvant therapy for malignant tumor.