| 摘要: |
| ［目的］探讨特比萘芬、氟康唑、伊曲康唑、制霉菌素体外抗口腔念珠菌的敏感性。［方法］采用NCCLS公布的M-27A方案微量液体稀释法分别测定特比萘芬、氟康唑、伊曲康唑、制霉菌素对38株临床分离的口腔念珠菌的体外敏感性。［结果］38株白念珠菌对氟康唑耐药4株，敏感34株；对伊曲康唑耐药5株，敏感33株；对特比奈芬耐药15株，敏感23株；制霉菌素均敏感。［结论］4种药物中氟康唑的敏感性相对较高，但仍有耐药现象，且氟康唑与伊曲康唑存在交叉耐药。 |
| 关键词: 口腔念珠菌 氟康唑 伊曲康唑 特比萘芬 制霉菌素 |
| DOI：10.11724/jdmu.2010.04.25 |
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| Observing the susceptibility of candida albicans to fluconazole terbinafine and itraconazole and nystatine by m27-a microdilution method |
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SONG Xiao-jing1, DONG Yan2, ZHANG Hong1, ZHENG Tong-jiao1
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1.Dapertment of Oral,the First Affiliated Hospital of Dalian Medical University,Dalian 116011,China;2.Oral Medical College,Dalian Medical University,Dalian 116044,China
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| Abstract: |
| ［Objective］To compare the susceptibility of candida albicans cultured with fluconazole,terbinafine,itraconazole and nystatine.［Methods］M27-A Microdilution Method based on NCCCLS was used to determine the susceptibility of 38 candida albicans isolates cultured with fluconazole,terbinafine,itraconazole and nystatine.［Results］Four fluconazole-resistance isolates,34 susceptible isolates,5 itraconazole-resistance isolates,33 susceptible isolates,15 terbinafine-resistance isolates and 23 susceptible isolates were detected from 38 clinical candida albicans isolates.［Conclusion］The susceptibility of candida albicans to fluconazole is the highest in the 4 drugs,but the resistance to fluconazole and cross-resistance between fluconazole and itraconazole are found in this study. |
| Key words: candida albicans fluconazole terbinafine itraconazole nystatine |
