肺炎支原体肺炎患儿临床特点及血清白细胞介素-2变化的临床意义

Study on serum levels of interleukin-2 and the clinical characters in children with mycoplasma pneumoniae pneumonia

关键词:  肺炎支原体肺炎  白细胞介素-2  儿童

Key words:  mycoplasma pneumoniae pneumonia  interleukin-2  child

摘要:

［目的］通过分析肺炎支原体肺炎（mycoplasma pneumoniae pneumonia，MPP）临床特点及患儿的血清中IL-2的变化，探讨MPP的发病机制，以期为临床合理诊治提供理论依据。［方法］随机选取已住院确诊的MPP患儿32例，正常儿为对照组20例。观察其临床症状及体征，同时取其静脉血用酶联免疫吸附试验（ELISA）方法检测血清IL-2水平，并进行单因素方差分析。［结果］（1）MPP以刺激性干咳及肺部体征不明显为临床特点，肺外表现多见。（2）MPP组、正常对照组儿童血清IL-2水平分别为（82.389±25.776）pg/mL，（121.482±46.335）pg/mL。MPP组与正常对照组相比血清IL-2水平降低，P<0.05。［结论］（1）刺激性干咳，肺部体征不明显，肺外表现多见为MPP临床特点。（2）IL-2水平的下调与MPP的发病机制相关，合理调整患儿IL-2水平有利于MPP的治疗。

Abstract:

［Objective］To investigate the immune state of children with MPP by evaluate the serum levels of IL-2 in children with MPP and to clarify the mechanism in order to provide evidence for determining the treatment strategy of MPP.［Methods］Thirty-two child inpatients diagnosed as mycoplasma pneumoniae pneumonia (MPP) were selected and twenty normal children were involved as control.The symptom and manifestation of the patients were recorded and the serum levels of IL-2 in all the groups were collected to be analyzed.Enzyme linked immunoassay（ELISA）was used to measure serum IL-2 level in the children.The data were processed by statistical software spss 12.0 and with significance when probability value was less than 0.05.［Results］(1)The clinical features of MPP were irritable dry cough and the pulmonary signs were not obvious.MPP had more extra pulmonary manifestation.(2)Serum levels of IL-2 in the MPP group and normal control group were (82.389±25.776)pg/mL,(121.482±46.335)pg/mL respectively.Serum level of IL-2 in the MPP group was significantly higher than those in the normal control group(P<0.05).［Conclusion］(1) Irritable dry cough is the clinical feature of MPP,and the pulmonary signs are not obvious.MPP has more extrapulmonary manifestation.(2) IL-2 plays a role in the pathogenesis in children with MPP.There may be more remarkable immune function disorders in children with MPP compared to children with non-MPP.Adjusted level of IL-2 may be a potential therapy in child MPP patients.