化疗及内分泌治疗对乳腺癌患者肝脏脂肪变性影响的研究进展

Progress of influence of chemotherapy and endocrine therapy on fatty liver in patients with breast cancer

关键词:  乳腺癌  化学疗法  内分泌治疗  脂肪肝

Key words:  breast cancer  chemotherapy  tamoxifen  endocrine therapy  fatty liver

摘要:

乳腺癌是女性中最常见的恶性肿瘤之一。对于乳腺癌的治疗除手术切除外，化疗和内分泌治疗是极其重要的治疗手段，而服用抗雌激素药物他莫昔芬的乳腺癌患者易诱发脂肪肝，并且近年其发病率明显增高。脂肪肝是应用他莫昔芬治疗的乳腺癌患者化疗期间和化疗后常见的并发症，是化疗药物对肝脏损伤的一种综合表现。乳腺癌化疗及内分泌治疗对肝脏脂肪变性影响的研究有利于加强医务工作者对脂肪肝的认识，从而能引起临床医生对此病的重视，并及早给予治疗。本文从脂肪肝的概述、乳腺癌化疗性脂肪肝、乳腺癌内分泌治疗方面对肝脏脂肪变性的影响进行了综述。

Abstract:

At present,breast cancer is one of the most common malignancies in women. Besides surgical resection, chemotherapy and endocrine therapy are extremely important treatments for patients with breast cancer.Tamoxifen (TAM), an anti-estrogen drug, is apt to induce fatty liver in breast cancer, and it increases the incidence of fatty liver obviously. Fatty liver usually happens during and after chemotherapy, and it is an integrated performance of chemotherapy-induced liver injury. Therefore, researching the influence of chemotherapy and endocrine therapy on fatty liver will be helpful for clinicians to understand more about the acknowledge of the disease and give timely treatment in patients with breast cancer. Chemotherapy induced and endocrine therapeutics induced fatty liver in patients with breast cancer are reviewed in this paper.