神经生长因子及其受体在肿瘤研究中的进展

Expressions of nerve growth factor and its receptor in breast cancer and its clinical significance

关键词:  神经生长因子  肿瘤  细胞凋亡

Key words:  nerve growth factor  tumor  apoptosis

摘要:

神经生长因子是一种多功能、多肽性的物质，通过特异的靶细胞表面的神经生长因子受体介导产生生物学效应。它对肿瘤细胞主要表现为抗凋亡的活性，具有强烈的促进肿瘤细胞生长的作用，与肿瘤的增殖、分化和转移有着密切的关系。高亲和力受体Trk A 与低亲和力受体p75在癌组织中均表达，研究表明Trk A与p75与肿瘤的预后、分级及肿瘤类型均相关。适当应用p75和Trk A的激动剂或抑制剂，可为更好的治疗肿瘤提供有效的办法。

Abstract:

Nerve growth factor is a multi-function and multi-peptide material.It produces biological effects through the nerve growth factor receptors on the specific target cell surface.It makes an anti-apoptosis activity to the tumor cells and promotes the growth of tumor cells.Trk A is a high-affinity receptor,influences on the transcription and translation of the cells and controls the growth of the cells.p75 is a low-affinity receptor.They are both expressed in the tumor cells.Many studies have showed that p75 and Trk A are related with the prognosis,grade and type of the tumor cells.The appropriate application of the p75 and Trk A agonists or inhibitors may play an effective solution on the treatment of the tumors.