| 摘要: |
| 金属β-内酰胺酶基因位于细菌染色体、质粒或者转座子上，并以基因盒的形式存在于整合子中，可在不同细菌间传递，导致耐药性水平播散。金属酶能水解除单环类以外的包括碳青霉烯在内的一大类β-内酰胺类抗生素。本文就金属酶的起源、分类、分子结构特点、分子生物学基础方面的研究作一综述。 |
| 关键词: 金属β-内酰胺酶 整合子 耐药 |
| DOI：10.11724/jdmu.2009.06.28 |
| 分类号:R446.5 |
| 基金项目: |
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| Advances in Metallo-beta-lactamases |
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ZHANG Feng-hua1, JIA Yu-jie2
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1.Department of Clinical Laboratory, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China;2.Department of Pathophysiology, Dalian Medical University, Dalian 116044, China
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| Abstract: |
| Metal beta-lactamases (MBL) gene is located in bacterial chromosomes, plasmid or transposon, and in the form of a cassette exists in integron. MBL can transmit drug-resistance through the gene recombination mechanism between the different bacteria and can hydrolysis a large class of beta-lactam antibiotics including the carbapenem except for single-loop class antibiotic. Here is the summary of currently research of MBL on the origins, classification, molecular characteristics and molecular biology research. |
| Key words: Metal beta-lactamases integron drug resistance |
