糖尿病患者的交感皮肤反应检测

Test of sympathetic skin response in patients with diabetes mellitus

关键词:  糖尿病  交感皮肤反应  交感神经

Key words:  diabetes mellitus  sympathetic skin response  sympathetic nerves

摘要:

［目的］ 探讨糖尿病患者周围交感神经受损的情况。［方法］ 对61例2型糖尿病患者和50例健康对照组进行了上下肢的交感皮肤反应（sympathetic skin response，SSR）检测。［结果］ SSR的起始潜伏期，上肢：糖尿病组（1385.3±246.7）ms与对照组（1361.2±123.2）ms差异具有显著性意义，P<0.001；下肢：糖尿病组（1858.9±527.5 ）ms与对照组（1742.8±225.2 ）ms差异有显著性意义，P<0.05；上下肢SSR波幅与对照组相比差异无显著性意义（P>0.05）。糖尿病组SSR总异常率为41%，上肢异常率为17%，下肢异常率为41%，下肢异常率明显高于上肢，P<0.001。［结论］ SSR是检测糖尿病交感神经损害的一种客观的、敏感的方法。此方法简单且无创伤，可作为糖尿病的常规电生理检测。

Abstract:

［Objective］ To study the injuries of peripheral sympathetic nerves in patients with T2DM(Type 2 diabetes mellitus). ［Methods］ SSR(Sympathetic skin response) was tested in extremities of 61 T2DM patients and 50 healthy controls. ［Results］ The initial latencies of SSR in upper limbs and lower limbs were prolonged significantly in T2DM group as compared to the control group [upper limbs: T2DM group(1385.3±246.7)ms, control group:(1361.2±123.2)ms, P<0.001; lower limbs:T2DM group(1858.9±527.5)ms, control group:(1742.8±225.2)ms, P<0.05]. There were no significant differences in Amplitudes of SSR between the two groups (P>0.05). The abnormal rate of SSR was 41% in T2DM group, 17% in upper limbs, 41% in lower limbs. The abnormal rate in lower limbs was significantly higher than in upper limbs (P<0.001). ［Conclusion］ SSR is an objective method to detect injuries of sympathetic nerves in patients with diabetes mellitus. The method is simple and harmless. SSR can be used as a routine electrophysiological test in diabetic patients.