| 摘要: |
| ［目的］ 探讨微卫星位点D8S1179、D21S11和D18S51的多态性及与精神分裂症相关的易感基因位点。［方法］ 对57例精神分裂症患者和62名随机人群采用PE Profiler plus系统进行PCR复合扩增，然后用ABI公司的310型基因分析仪自动进行电泳分离和基因检测。［结果］ 精神分裂症组D8S1179-14 的检出率为30.7%，对照组检出率为19.5%，两者差异有显著性意义（P<0.05）；D21S11、D18S51位点的各等位基因频率的检出率在两组间差异无统计学意义（P>0.05）。经吻合度检验，3个微卫星标记上各等位基因频率的分布，均符合Hardy-Weinberg平衡。［结论］ D8S1179-14位点可能与精神分裂症发病有关。 |
| 关键词: 精神分裂症 微卫星DNA多态 第8号染色体 |
| DOI：10.11724/jdmu.2009.05.02 |
| 分类号:R749.3 |
| 基金项目: |
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| Relationship between polymorphism of gene D8S1179,D21S11,D18S51 and schizophrenia |
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YANG Guang, LUO Hong, SUN Wen-ping, LIU Hui
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Department of Clinical Immunology and Microbiology, Dalian Medical University, Dalian 116044, China
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| Abstract: |
| ［Objective］ To explore a genetic relationship between HLA loci including D8S1179, D21S11, D18S51and schizophrenia.［Methods］ DNA samples were collected from patients with schizophrenia(n=57) and random population(n=62) in China. The D8S1179, D21S11 and D18S51, three short tandem repeats, were determined with the STR Profiler Plus PCR amplification kit. ［Results］ Frequency of D8S1179-14 in schizophrenia group(F=30.7%) was higher than that in control group (F=19.5%) (P<0.05).There were no significant difference in frequencies of D21S11 and D18S51 between the schizophrenia group and the control group (P>0.05). No deviations from the Hardy-Weinberg equilibrium were observed. ［Conclusion］ Gene associated with susceptibility to schizophrenia may exist in the microsatellite marker region D8S1179-14 of the chromosome 8. |
| Key words: schizophrenia microsatellite DNA chromosome 8 |
