“和胃饮”合剂对功能性消化不良大鼠胃肠激素的影响

Effect of Heweiyin mixture on gastrointestinal hormone in rats with functional dyspepsia

关键词:  和胃饮合剂  功能性消化不良  胃动素  胃泌素  一氧化氮

Key words:  Heweiyin mixture  functional dyspepsia  gastrin  Motilin  Nitric oxide

摘要:

［目的］ 观察“和胃饮”合剂对功能性消化不良（FD）大鼠胃肠激素的影响，以探讨其促胃动力的作用机制。［方法］ 采用激怒法制备FD大鼠模型。放射免疫法及分光光度法分别测定血中胃动素（MTL）、胃泌素（GAS）水平及一氧化氮（NO）含量。 ［结果］高剂量组、低剂量组和FD组血浆MTL分别为246.20±94.88，163.80±28.15和130.94±18.43，各组间差异有显著性意义（P<0.05）；血清GAS分别为64.36±18.02，57.44±14.44和30.34±6.27，用药组明显高于FD组 （P<0.05）；NO 含量分别为：33.79±5.96，37.93±11.65和63.20±15.44，各组间差异有显著性意义（P<0.05）。 ［结论］ “和胃饮”合剂的促胃动力作用可能与其增加FD大鼠血浆MTL、血清GAS水平和降低NO含量作用有关。

Abstract:

［Objective］ The purpose of study is to observe the effect of Heweiyin Mixture (HWYM ) on gastrointestinal hormone in rats with functional dyspepsia(FD) and thereby investigate its’ gastro-prokinetic mechanism. ［Methods］ Functional dyspepsia model was prepared in rats using anger method. Plasm motilin (MTL), serum gastrin (GAS) were methoded by RIA, nitric oxide (NO) was determined by spectrophotometry. ［Results］ In high dose, low dose and model group, plasm MLT were 246.20±94.88,163.80±28.15 and 130.94±18.43, respectively (P<0.05); serum GAS were 64.36±18.02, 57.44±14.44 and 30.34±6.27, respectively (P<0.05); No were 33.79±5.96, 37.93±11.65 and 63.20±15.44, respectively (P<0.05). ［Conclusion］ The gastro-prokinetic mechanism effect of HWYM is related to its ability to increase level of plasma MTL, serum GAS and to decrease the content of plasm nitric oxide.