| 摘要: |
| 维生素D(VitD)是一组具有广泛生理作用的类固醇衍生物，其作用是通过VitD受体(VDR)介导的。体内大多数组织和细胞都有VDR。VitD抵抗是指机体对正常甚至大剂量VitD或1，25(OH)2D的低反应或无反应现象，VDR基因点突变是主要原因之一，对机体有着多方面影响。 |
| 关键词: 维生素D 维生素D受体 维生素D抵抗 |
| DOI：10.11724/jdmu.2009.03.34 |
| 分类号:Q56 |
| 基金项目: |
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| Progress in vitamin D receptor and vitamin D resistance |
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ZOU Ning1, LI Xiao-huan2
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1.Department of, Gynecology and Obstetrics Hospital of Dalian, Dalian 116033, China;2.Department of Nursing, Dalian Medical University, Dalian 116044, China
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| Abstract: |
| Vitamin D (VitD) is a group of steroid derivatives with a wide range of biological actions. VitD acts through its receptor (VDR). Most tissues and cells in the body have VDR. The phenomenon of low or no reaction to normal and even pharmacological dosages of vitamin D or 1, 25 (OH)2D is called vitamin D resistance. The point mutation of VDR gene is one of the causes of vitamin D resistance, which has extensive affects on human body functions. |
| Key words: Vitamin D vitamin D receptor vitamin D resistance |
