血清脂联素、超敏C反应蛋白、肿瘤坏死因子-α水平变化与发生急性冠脉综合征的相关性分析

Correlation between serum adiponectin, hypersensitive C-reaction protein, tumor necrosis factor and acute coronary syndrome

关键词:  急性冠脉综合征  脂联素  超敏C反应蛋白  肿瘤坏死因子

Key words:  acute coronary syndrome  adiponectin  hypersensitive C-reaction protein  tumor necrosis factor

摘要:

［目的］ 探讨急性冠脉综合征（ACS）患者炎性因子水平与冠状动脉粥样硬化病变程度的关系。［方法］ 对入选64例临床诊断的ACS患者，其中33例急性心肌梗死（AMI），31例不稳定性心绞痛（UAP）和30例正常对照者，应用放射免疫、散射比浊和酶联免疫吸附的方法对血清脂联素（APN） 、高敏C-反应蛋白（H-CRP） 、肿瘤坏死因子（TNF-α）水平进行检测。［结果］ AMI组APN浓度为（8.96±3.1）mg/L，H-CRP浓度为（8.26±5.54）mg/L，TNF-α浓度为（23.0±7.0）pg / mL；UAP组APN浓度为（9.90±4.31）mg/L，H-CRP浓度为（6.14±3.45）mg/L，TNF-α浓度为（20.0±6.0）pg / mL；对照组APN浓度为（13.84±4.37）mg/L，H-CRP浓度为（1.37±0.64）mg/L，TNF-α浓度为（14.0±5.0）pg / mL。ACS各组的APN、H-CRP、TNF-α水平与正常对照组比较有显著性意义（P<0.01）。［结论］ APN、H-CRP、TNF-α水平变化与ACS发生、发展密切相关,是发生ACS的重要的危险因素。

Abstract:

［Objective］ This investigation is to explore the relationship between level of inflammatory factors with acute coronary syndrome (ACS) and the severity of coronary atherosclerosis. ［Methods］ Sixty-four patients with chest pain in hospital diagnosed as ACS, were involved in this study. According to different clinical manifestations and coronary angiography (CAG), they were divided into two groups. There were 30 healthy controls in this study. Fasting plasma adiponectin (APN), hypersensitive c-reaction protein (H-CRP), tumor necrosis factor (TNF) were assayed by radioimmunoassay, electro-chemiluminescence and ELISA. ［Results］ Level of APN, H-CRP, TNF in two disease groups were significant difference than those in the control group, P<0.01. Plasma concentrations of adiponectin in disease group were significantly lower than those in the control group, P<0.01. ［Conclusions］ Plasma level of APN, H-CRP and TNF may be related to the development of ACS and may be an important risk factor.