| 摘要: |
| ［目的］观察干酪菌发酵产物对豚鼠离体回肠平滑肌的作用。［方法］采用豚鼠离体回肠平滑肌标本，观察加入干酪菌发酵产物前后肌紧张和收缩幅度的变化。给药浓度分别为ZPL 1.5×103mg/L、3.0×103mg/L、6.0×103mg/L、12.0×103mg/L、18.0×103mg/L、24.0×103mg/L。［结果］干酪菌发酵产物3.0×103mg/L、6.0×103mg/L、12.0×103mg/L豚鼠离体回肠平滑肌肌紧张分别为123%、132%、138%，组间比较差异有显著性意义（P<0.01）；6.0×103mg/L、12.0×103mg/L、18.0×103mg/L豚鼠离体回肠平滑肌收缩幅度分别为171%、316%、354%，组间比较差异有显著性意义（P<0.01）。［结论］干酪菌发酵产物能提高豚鼠离体回肠平滑肌肌紧张和收缩幅度，且呈剂量－效应依赖关系。 |
| 关键词: 干酪菌发酵产物 离体回肠 豚鼠 |
| DOI：10.11724/jdmu.2009.01.13 |
| 分类号:R282.71；R285.1 |
| 基金项目: |
|
| Experimental studies of ZPL on muscular tension and contraction amplitude of isolated ileum of guinea pig |
|
WANG Jun1,2, ZOU Yuan3, DU Yu-guang2
|
|
1.Department of Natural Products and Gly-Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China;2.Department of Physiology, College of Medicine, Dalian University, Dalian 116622, China;3.Department of Physiology, Dalian Medical University, Dalian 116044, China
|
| Abstract: |
| ［Objective］To study the effects of zymotic fluid of polypor laetiporus (ZPL) on smooth muscular tension and contraction of isolated ileum of guinea pig.［Methods］Isolated guinea pig ileum was incubated in an organ bath, and muscle tense and contraction amplitude were observed. The dose of ZPL were 1.5×103mg/L, 3.0×103mg/L, 6.0×103mg/L,12.0×103mg/L,18.0×103mg/L, 24.0×103mg/L.［Results］ZPL 3.0×103mg/L, 6.0×103mg/L,12.0×103mg/L increased muscle tense, Which was 123%,132%,138% respectively; and ZPL(6.0×103) mg/L,(12.0×103) mg/L, (18.0×103) mg/L increased contraction amplitude, Which was 123%,132%,138% respectively.［Conclusion］ZPL could significantly augment the spontaneous contraction of pig ileum with dose dependent manner. |
| Key words: zymotic fluid of polypor laetiporus isolated ileum guined pig |
