超敏C反应蛋白在健康体检中的意义

Significance of high sensitivity C-reactive protein in medical examination

关键词:  超敏C反应蛋白  血脂  心、脑血管疾病  健康体检

Key words:  high sensitivity C-reactive protein  blood lipids  heart or brain blood vessel disease  medical examination

摘要:

［目的］探讨超敏C反应蛋白（HS-CRP）作为心、脑血管疾病的常规筛查指标，在正常人群健康体检中的意义。［方法］选取本院健康体检者310例，排除能引起C反应蛋白升高的炎性疾病，在OlympusAU2700全自动生化分析仪上，用乳胶增强免疫透射比浊法测定血清中的HS-CRP，同步测定血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）等4项血脂指标，并进行对比分析。［结果］单纯血脂检测，高脂血症者108例，心、脑血管疾病危险因素的检出率为34.8%；单纯HS-CRP检测，升高者86例，检出率27.7%；血脂与HS-CRP同时检测,异常者145例,检出率46.7%。血脂、HS-CRP单独检测与两者同时检测比较，P值均<0.01，差异具有非常显著性意义。［结论］HS-CRP与血脂同时检测，能筛查出30%~40%用常规血脂检测未发现的具有心、脑血管疾病的潜在危险者。HS-CRP在心、脑血管疾病预测中具有重要价值。应作为血脂的补充检测指标，用于健康人群体检中，以提高心、脑血管疾病的预报率。

Abstract:

［Objective］To discuss the significance of high sensitivity C-reactive protein(HS-CRP) in medical examination of healthy people as a routine determined index.［Methods］Three hundred and ten cases of medical examination people in our hospital were celected,excluding the inflammation disease that could make HS-CRP risen.The levels of HS-CRP in serum were determined by particle enhanced Immuoturbidimetric method at the analysis instrument of OlympusAU2700.The total cholesterin(TC),triglyceride(TG),high density lipoprotein cholesterin(HDL-C)and low density lipoprotein cholesterin(LDL-C)were determined at the same time and were contrasted with HS-CRP.［Results］108 cases of high lipids people were found by determining blood lipids solely and the positive rate was 34.8%.86 cases of high HS-CRP people were found by determining HS-CRP solely and the positive rate was 27.7%.But if the both were determined at the same time , the positive rate was 46.7%.The positive rates of determining HS-CRP and blood lipids solely were compared with the positive rate of determining them at the same time,the difference had very prominent significance (P＜0.01).［Conclusion］HS-CRP and blood lipids are determined at the same time, we can find 30%~40% latent patients of heart or brain blood vessel disease. HS-CRP is important in forecasting heart or brain blood vessel disease.It should be used as a complementary determined index in medical examination of healthy people,in order to advance the forecast rate of heart or brain blood vessel disease.