胃肿瘤CT灌注成像临床价值的初步探讨

Preliminary clinical evaluation of CT perfusion imaging of stomach neoplasm

关键词:  CT  计算机辅助  胃肿瘤

Key words:  CT  Computer-assisted  gastric neoplasm

摘要:

［目的］ 探讨胃肿瘤CT灌注成像的可行性，评价其在胃肿瘤性病变诊疗中的初步价值。［方法］对13例胃肿瘤患者进行了4排和16排CT灌注成像扫描。采用CT电影扫描技术对肿瘤中心层面进行灌注扫描，层厚10 mm/2i；使用高压注射器经右肘前静脉快速团注造影剂，剂量45～50 mL，注射速度3.5～4.0 mL/s，扫描延迟时间5 s，扫描总时间45 s。利用胰腺模式进行CT灌注数据的处理，计算血流量(BF)、血容量(BV)、平均通过时间(MTT) 以及表面渗透性(PS)。［结果］正常胃壁的BF、BV、MTT、PS分别为(357.24±212.44) mL/(min·100 g)、(16.53±9.78) mL/100 g、(4.29±3.12) s、(36.40±39.54) mL/(min·100 g)；胃肿瘤的则为(62.18±38.1) mL/(min·100 g)、(5.21±4.58) mL/100 g、(11.79±8.18) s、(13.09±12.62) mL/ (min·100 g)，P值分别为0.0017、0.014、0.04和0.036。［结论］CT灌注成像可提供胃肿瘤的血流动力学信息，在胃肿瘤的诊断中有一定价值，其临床应用前景广阔。

Abstract:

［Objective］The purpose of this study is preliminarily to discuss perfusion imaging technique with Multi-slice CT and its clinical application value of diagnosis in stomach neoplasm.［Methods］Thirteen patients with known stomach neoplasm performed perfusion imaging with 4 or 16-slice CT. Performing perfusion imaging in central slice of neoplasm, using CT cine scan, slice thick 10 mm/2i; with high pressure syringe, injecting quickly from right elbow-front vein, dosage 45～50 mL, injection rate (3.5～4.0) mL/s, scanning delay time 5 s, scanning total time 45 s. We performed perfusion CT post-processing using pancreatic mode of Perfusion CT software. Blood flow (BF), blood volume (BV), mean transit time (MTT), and permeability surface (PS) of gastric wall were computed for every case.［Results］BF, BV, MTT and PS of normal gastric wall were (357.24±212.44) mL/(min·100 g),(16.53±9.78) mL/100 g,(4.29±3.12) s,(36.40±39.54) mL/(min·100 g); for gastric tumors were (62.18±38.1) mL/(min·100 g),(5.21±4.58) mL/100 g,(11.79±8.18) s,(13.09±12.62) mL/(min·100 g) respectively. The P values for perfusion CT parameters between gastric tumors and normal gastric wall were 0.0017,0.014,0.04 and 0.036, respectively.［Conclusions］Perfusion CT can provide hemodynamics of gastric tumors and play a key role in the diagnosis of gastric tumors. It's clinical application prospect will be fully broad.