| 摘要: |
| ［目的］检测胃癌组织中P53、PTEN蛋白的表达情况，进一步探讨它们在胃癌发生发展过程中的作用。［方法］免疫组织化学方法检测胃癌、癌旁及胃炎组织中P53和PTEN蛋白表达情况。［结果］P53蛋白在胃癌组织中的表达率为88.7%，明显高于胃炎（23,5%）及癌旁组织（11.3%）的表达率（P<0.05）。PTEN蛋白在胃癌组织的表达率为64.5%，明显低于胃炎组织的表达率（91.2%，P<0.05）。在55例P53蛋白表达的胃癌组织中，21例不表达PTEN蛋白；在7例P53蛋白表达阴性的胃癌组织中，仅1例不表达PTEN蛋白。［结论］胃癌组织中P53蛋白表达上调，PTEN蛋白表达下调。 |
| 关键词: 胃癌 P53 PTEN |
| DOI：10.11724/jdmu.2008.04.05 |
| 分类号:Q279 |
| 基金项目: |
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| P53 and PTEN protein expression in gastric carcinoma |
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HU Shao-wei1, ZHANG Wei-bin1, XIAO Gang1, SHI Ling-chun1, Lü Shen2
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1.Department of Pathology, Traditional Chinese Medicine Hospital of Guangdong Province, Guangzhou 510120, China;2.The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China
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| Abstract: |
| ［Objective］To detect the expression of P53 and PTEN proteins,in gastric carcinoma.［Methods］The immunohistochemical method was used to examine the expression of P53 and PTEN proteins in gastric carcinoma, paratumorous lesions and gastritis.［Results］The positive rate of P53 expression was 88.7% in gastric carcinoma, which was significantly higher than that in paratumorous lesions (11.3%) and gastritis (23.5%) respectively (P<0.05). The positive rate of PTEN expression was 64.5% in gastric carcinoma, which was significantly lower than that in gastritis (91.2%, P<0.05). In 55 cases of gastric carcinoma with P53 protein expression, 21 cases did not express PTEN protein,while in 7 cases of gastric carcinoma without P53 protein expression,only one case did not express PTEN protein.［Conclusions］The higher expression of P53 protein and the lower expression of PTEN protein may exist in gastric carcinoma. |
| Key words: gastric carcinoma P53 PTEN |
