15例子宫内膜浆液性乳头状癌临床资料分析

Clinical analysis of 15 cases of uterine papillary serous carcinoma

关键词:  子宫内膜浆液性乳头状癌  临床病理  治疗

Key words:  Papillary serous carcinoma  clinical pathology  treatment

摘要:

［目的］探讨子宫内膜浆液性乳头状癌(uterine papillary serous carcinoma，UPSC)的临床病理特征以及合理的治疗方法。［方法］对1995年1月～2007年12月收治的15例UPSC患者进行回顾性研究，对其发病趋势、危险因素、临床表现、病理特征、诊断方法和治疗方案进行分析。［结果］ 平均发病年龄63.8岁，80%患者雌孕激素受体阴性，53.3%患者术后手术病理分期高于术前临床分期，P53在60%患者中有表达，中晚期患者血清CA-125水平均有升高。所有患者均接受手术治疗，多数术后辅助化疗、放疗，生存率仍较低。［结论］UPSC不同于子宫内膜样腺癌，具有其特殊性，恶性程度较高，预后差。合理的个体化综合治疗可提高生存率。

Abstract:

［Objective］To investigate the clinical and pathologic characteristics, and search the rational therapy for uterine papillary serous carcinoma(UPSC).［Methods］A retrospective study was conducted on incidence,risk factors,clinical characters,pathological feature, diagnosis and treatment of 15 patients with UPSC, who was admitted from Jan.1995 to Dec.2007.［Results］Median age at diagnosis was 63.8 years. Among all the patients with UPSC, 80% presented negative estrogen and/or progestin receptor,53.3% diagnosed as higher stage post operative than preoperative staging;and 60% presented positive P53.The level of CA-125 in serum elevated among middle-late stage patients. All the patients underwent operation, and a great part received postoperative radiotherapy and／or chemotherapy. The survival rate was still lower.［Conclusions］UPSC is highly malignant,which has different clinical and pathological characteristics from the endometrioid carcinoma. Rational individualized treatment may lengthen survival time.