| 摘要: |
| 整合子具有特异性整合位点,能够整合外来的耐药基因。一般定位在质粒或转座子上，广泛分布在革兰氏阴性菌中，是耐药基因在病原菌间水平传播的重要因子。本文参考近年国外相关文献,就整合子的结构、功能、分类、分布与传播及检测方法作一综述。 |
| 关键词: 整合子 质粒 多重耐药 |
| DOI：10.11724/jdmu.2008.02.30 |
| 分类号:Q78 |
| 基金项目: |
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| Integron Gene Cassttes:researching progress of bacterial resistance |
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WANG Huan1, FAN Xiao-lei2
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1.The Second Affiliated Hospital of Dalian Medical University, Dalian 116031,China;2.Department of Microbiology, Dalian Medical University, Dalian 116044,China
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| Abstract: |
| Integrons are known to be a novel mechanism for dissemination of resistance genes among gram-negative bacteria. The horizontal transfer of integrons may account for the dissemination of resistance genes and the emergence of multiresistant strains. This overview discusses the configuration, function, classify, distribution, transfer and detection of integrons. |
| Key words: integron plasmid multi-drug resistance |
