| 摘要: |
| ［目的］评价FOLFOX4方案治疗晚期大肠癌的疗效和不良反应。［方法］ 草酸铂（L-OHP）85 mg/m2 静脉滴入，第1天；甲酰四氢叶酸（CF）200 mg/m2，静滴2 h，第1、2天；CF后5-氟尿嘧啶（5-FU）400 mg/m2 快速静脉滴入，继以5-FU 600 mg/m2 持续静脉滴入22 h，第1、2天，2周重复，4周为1个周期。［结果］全组CR 1例，PR 10例，SD 17例，PD 9例，总有效率29.7%，初治有效率38.1%，复治有效率18.8%。主要不良反应为消化道反应及外周神经毒性。［结论］FOLFOX4是安全、有效，毒性可耐受的治疗晚期大肠癌的化疗方案，对初治患者效果优于复治患者。 |
| 关键词: 大肠癌 草酸铂 化学疗法 |
| DOI：10.11724/jdmu.2008.02.22 |
| 分类号:R735 |
| 基金项目: |
|
| FOLFOX4 combination chemotherapy in treatment of advanced colorectal carcinoma |
|
YANG Xiao-yan, JIANG kui, HAN mei, ZHANG Yang, LIU Fang
|
|
Department of Oncology,the Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China
|
| Abstract: |
| ［Objective］To evaluate the effectiveness and toxicity of oxaliplatin fluoriouracil and folinic acid combination chemotherapy in the treatment of advanced gastric carcinoma and colorectal carcinoma.［Methods］All cases received oxaliplatin 85 mg/m2 as a 2-hour infusion on day 1 and 2-hour infusion of LV 200 mg/m2 followed by a 5-FU bolus 400 mg/m2 and 22-hour infusion 600 mg/m2 for 2 consecutive days every 2 weeks. The regiment was repeated every 28 days.［Results］There were 1 CR, 10 PR, 17 SD and 9 PD in the group. The overall response rate was 29.7%. The major toxic reactions were nausea, vomiting and peripheral neurotoxicity.［Conclusion］FOLFOX4 combination chemotherapy is positively effective and safe in colorectal carcinoma. The toxicity is mild to moderate and reversible. |
| Key words: colorectal oxaliplatin chemotherapy |
