| 摘要: |
| 青光眼是当今世界范围内的主要致盲性眼病之一。青光眼的主要危险因素是高眼压，骤然升高的眼压产生神经兴奋毒性，引起视网膜神经节细胞(retinal ganglion cell,RGC )死亡，最终导致视神经进行性损害。目前的研究发现非竞争性N-甲基-D-天冬氨酸(N-methyl-D-aspartate，NMDA)受体拮抗剂美金胺（Memantine）可有效减少高眼压所致的视神经损害。 |
| 关键词: 美金胺 急性高眼压；视神经保护 |
| DOI：10.11724/jdmu.2008.01.28 |
| 分类号:R775 |
| 基金项目: |
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| Evoluation on neuroprotection of Memantine in acute elevated IOP |
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LI Yan-li, LI Jing-min
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Department of Ophthalmology,the Second Affiliated Hospital of Dalian Medical University，Dalian 116027,China
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| Abstract: |
| Glaucoma is one of the world's major causes of blind eye diseases. The main risk factors of glaucoma is high intraocular pressure（IOP）.The rush elevated IOP produces neuronic excitotoxicity.It can cause retinal ganglion cells (RGC) death and lead to the damage of nervus opticus finaly. The study of current found that N-methyl-D-aspartate (NMDA) memantine ,an uncompetive N-methyl-D-aspartate (NMDA) receptor antagonist, can dramatically reduce the degree of nervus opticus damage caused by Acute elevated IOP. |
| Key words: Memantine acute elevated IOP neuroprotection |
