血清神经元特异性烯醇化酶（NSE）和S-100B蛋白对急性脑梗死患者预后评估的临床意义

Predictive value of NSE and S-100B protein in patients with acute cerebral infarction

关键词:  脑梗死  神经元特异性烯醇化酶（NSE）  S-100B蛋白

Key words:  ACI  NSE  S-100B protein

摘要:

［目的］ 分析急性脑梗死患者血清神经元特异性烯醇化酶（NSE）和S-100B蛋白浓度变化,探讨其在脑梗死预后评估中的价值。［方法］ 采用电化学发光免疫分析技术（ECLIA）和酶联免疫吸附法（ELISA）分别测定57例脑梗死患者和20例正常人血清NSE和S-100B蛋白浓度。应用SSPS11.5软件包进行统计学处理。［结果］ 患者组NSE和S-100B蛋白浓度与对照组之间差异有显著性意义（P<0.01），患者组间差异也有显著性意义（P<0.01），NSE和S-100B蛋白浓度与病情严重程度和预后之间存在相关性（P<0.01）。［结论］急性脑梗死患者血清NSE和S-100B蛋白浓度均明显增高。NSE和S-100B蛋白浓度高低不仅可以给神经元和神经胶质细胞的损伤程度提供定量信息，而且也是判断病情，评估预后的重要参数。

Abstract:

［Objective］To evaluate the role and clinical significance of serum neuron specific enolase（NSE）and S-100B protein in the patients with acute cerebral infarction （ACI）.［Methods］Electrochemiluminescence immunoassay（ECLIA）was use to measure the seram NSE and ELISA to S-100B protein levels of 57 ACI patients and 20 normal control.Comparison analyze were performed by using a spss11.5 statisfical package.［Results］Patients with ACI were significantly higher than control group （P<0.01），and were significantly different between acute cerebral infarction group and recovery cerebral infarction group.There was a significant correlation of NSE and S-100B protein levels with the extant of the neurologic damage and prognosis（P<0.01）.［Conclusions］The levels of the serum NSE and S-100B protein remarkably increase in the patients with ACI.The acternation of NSE and S-100B protein not only provides quantitative information about the degree of certain neurologic lesions ，but also serves as an important parameter of assessing the prognosis.