海南黎族血管紧张素原基因多态性及生活习惯与原发性高血压并脑梗死易感性的关系

Relationship between polymorphism of angiotensinogen gene, dietary habits and risk of essential hypertension complicated by cerebral infarction in Hainan's Li nation

关键词:  血管紧张素原基因  原发性高血压并脑梗死  吸烟  饮酒  槟榔嗜好

Key words:  angiotensinogen gene  essential hypertension complicated by brain infarction  smoking  alcohol drinking  pinang propensity

摘要:

［目的］研究血管紧张素原基因C -18T多态性及烟酒槟榔嗜好相互作用与原发性高血压并脑梗死(PHACI)易感性的关系。［方法］ 选择海南黎族人群为研究对象，采用病例对照研究方法，调查其生活习惯，利用PCR-直接测序法检测C -18T的基因型。［结果］病例组AGT 基因-18TC基因型的频率显著高于对照组(χ²=9.783，P=0.002)，病例组T等位基因的频率也显著高于对照组（χ²=9.375，P=0.002）。此外研究还显示：AGT基因 -18TC基因型与吸烟、饮酒、槟榔嗜好无显著相互作用。［结论］当海南黎族个体携带TC基因型时，原发性高血压并脑梗死的易感性增加，该种基因型与吸烟、饮酒、槟榔嗜好相互作用，没有增加PHACI的易感性。

Abstract:

［Objective］To evaluate the relationship of between angiotensinogen (AGT) gene -18C/T polymorphisms, dietary habits and the risk of essential hypertension complicated by brain infarction(PHACI) in HaiNan’s Li nation.［Methods］The dietary habits data were collected by case-control study. -18C/T polymorphisms of AGT gene was determined by the method of PCR-sequencing.［Results］The frequency of TC in PHACI cases was significantly higher than those in controls(χ²=9.783，P=0.002). The frequency of T allele in PHACI cases was significantly higher than that of controls(χ²=9.375，P=0.002). In addition, no interaction was observed between TC genetype and smoking ,alcohol drinking or pinang propensity.［Conclusions］The AGT gene -18TC genetype might increase the risk of PHACI development in HaiNan's Li nation.