| 摘要: |
| 肝纤维化是大多数慢性肝病所共有的病理特征, 是一个多因素相互作用的结果。如何对其做出准确诊断是临床上的中心问题。肝组织活检是肝纤维化的诊断标准,但有其局限性；生化指标和肝组织病理学纤维化程度有较好相关性,有助于肝纤维化的非创伤性诊断。目前应用于临床的有HA、PCⅢ、LN、CⅣ、TNF-α、TGF-β、IL-1、IL-10、PDGF、可溶性细胞间黏附分子-1(sICAM-1) 等一系列生化指标。本文将对它们在诊断肝纤维化中的应用进行综述。 |
| 关键词: 肝纤维化 生化指标 肝组织活检 |
| DOI：10.11724/jdmu.2007.04.27 |
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| Determination and significance of biochemical index in hepatic fibrosis |
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YU Zhao-jia1, LIU Ke-xin2
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1.Seven Year Department 2003 Session of Dalian Medical University, Dalian 116027, China;2.Dept of Clinical Pharmacology，Dalian Medical University，Dalian 116027, China
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| Abstract: |
| Hepatic fibrosis is the common pathologic characteristic in many kinds of chronic liver diseases. It results from interaction of many factors. To diagnose accurately is the central problem in clinic. Though liver biopsy is the Goldden criteria for diagnosis of hepatic fibrosis it also has limitations. Biochemical indexes which are correlated with the degree of pathologic hepatic fibrosis are useful in non-invasive diagnosis of hepatic fibrosis. A series of biochemical indexes have been applied in clinic, eg: HA,PCⅢ,LN,CⅣ,TNF-α,TGF-β,IL-1,IL-10,PDGF,sICAM-1 and so on. |
| Key words: hepatic fibrosis biochemical indexes liver biopsy |
