糖尿病微血管病变患者血清一氧化氮的改变

Relationship between plasmic levels of nitric oxide and microvessel changes in diabetes mellitus

关键词:  糖尿病微血管病变  血清；一氧化氮

Key words:  diabetic microangiopathy  blood serum NO

摘要:

［目的］探讨血清一氧化氮对糖尿病微血管病变的影响的临床意义。［方法］将糖尿病微血管病变患者分为早期和晚期两型后，与糖尿病无微血管病变患者和正常对照组相对照，并以系列亚硝酸钠作标准对照，比色法测定血清NO^-2/NO^-3。［结果］糖尿病无微血管病变组血清NO^-2/NO^-3值明显增高,为69.1±25.4。糖尿病微血管病变早期组血清NO^-2/NO^-3值增高更显著,为82.5±29.3，而糖尿病微血管病变晚期组血清NO^-2/NO^-3值为68.9±24.7。［结论］非胰岛素依赖型糖尿病(NIDDM)患者血清NO增高与糖尿病微血管病变的发生、发展密切相关,其早期显著而晚期趋缓。

Abstract:

［Objective］To investigate the clinical significance of NO in diabetic microangiopathy.［Methods］After classification of diabetic patients, diabetic patients with microangiopathy was classificated into pervious microangiopathy and serious microangiopathy, and NO^-2/NO^-3 was detected by colorimetry, with standard control of sodium nitrite.［Results］NO^-2/NO^-3 in diabetic patients without microangiopathy was obviously higher than that in control group，was 69.1±25.4. NO^-2/NO^-3 in diabetic patients with pervious microangiopathy was (82.5±29.3)mol/L, and became significantly higher .but NO^-2/NO^-3 in diabetic patients with serious microangiopathy was (68.9±24.7)μmol/L［Conclusions］The increase of NO in NIDDM was associated with the progress of diabetic microangiopathy.