心肌组织多普勒成像技术评估肥厚型心肌病左室收缩运动协调性及功能

Assessment of systolic synchrony and function of left ventricular motion in hypertrophic cardiomyopathy by myocardial tissue Doppler imaging

关键词:  肥厚型心肌病  左室收缩协调性  左室收缩功能  组织多普勒成像

Key words:  hypertrophic cardiomyopathy  left ventricular systolic synchrony  left ventricular systolic function  tissue doppler imaging

摘要:

［目的］应用组织多普勒成像技术（TDI）评价肥厚型心肌病(HCM)左室收缩运动协调性及功能。［方法］ 正常对照组18例、肥厚型心肌病患者30例。测量左室收缩期电机械运动的时间离散度（D_TQ-S）、室间隔和左室侧壁6个位点的心肌收缩期峰值速率（Vs）。［结果］与对照组（15.6±3.5）ms相比，HCM组D_TQ-S延长，梗阻型（31.5±12.3 ）ms、非梗阻型（28.2±15.2）ms均为P<0.001，而二者之间比较差异无显著性意义（P=0.623）。HCM组各位点Vs值降低(P<0.05），但是梗阻型与非梗阻型相比差异均无显著性意义。［结论］肥厚型心肌病梗阻型与非梗阻型均存在左室收缩运动协调障碍和收缩功能下降，TDI能够评价HCM左室运动而不受负荷影响。

Abstract:

［Objective］To assess left ventricular systolic synchrony and systolic function in hypertrophic cardiomyopathy by Tissue Doppler Imaging (TDI) technique.［Methods］Thirty patients with hypertrophic cardiomyopathy (HCM) and 18 age-matched healthy subjects as control group were performed with Pulsed TDI to record the ventricular septum and left ventricular lateral、anterior and inferior walls motion pattern in the left side atrial-ventricular annulus. The time dispersion of electromechanical motion in left ventricular systole、systolic velocity (Vs) at six sites in ventricular septum and left ventricular lateral wall were measured.［Results］Compared with control group(15.6±3.5)ms，The time dispersion of electromechanical motion in left ventricular systole significant increased in HCM group (31.5±12.3) ms obstructive HCM, (28.2±15.2)ms non-obstructive HCM, P<0.001, but there was no significant difference between experiment groups (P=0.623). Vs in left ventricular segments of HCM group were lower than that of control group ( P<0.05 ), and there was no significant difference between obstructive and non-obstructive groups in HCM patients .［Conclusions］Impairment of systolic synchrony of left ventricular motion and systolic function exists in obstructive and non-obstructive groups in HCM patients . TDI can assess left ventricular motion in HCM patients independence of the load.