芬太尼透皮贴剂联合可乐定治疗急性带状疱疹疗效观察

Effectiveness of transdermal fentanyl combined with clodine for pain control of acute herpes zoster

关键词:  芬太尼透皮贴剂  可乐定  带状疱疹  疱疹后神经痛

Key words:  transdermal fentanyl  clodine  herpes zoster  postherpetic neuralgia

摘要:

［目的］观察芬太尼透皮贴剂(多瑞吉) 联合可乐定对急性带状疱疹的治疗效果。［方法］选择60例病人随机分为两组，芬太尼透皮贴剂治疗组(F组)和芬太尼透皮贴剂联合可乐定治疗组(C组)，观察患者疼痛的缓解程度、生活质量的改善、出现的并发症以及疱疹后神经痛发生率。［结果］C组较F组缓解疼痛更明显,差异有显著性意义（P< 0.05）。并发症与疱疹后神经痛发生率减少。［结论］多瑞吉联合可乐定能有效地控制急性带状疱疹疼痛及疱疹后神经痛的发生,并改善病人的生活质量。

Abstract:

［Objective］To observe the therapeutic effect of transdermal fentanyl in patients with acute Herpes Zoster and the incidence of Postherpetic Neuralgia(PHN).［Methods］Sixty patients were devided randomly into transdermal fentanyl group(F group, n=31) and transdermal fentanyl combined with Clodine group(C group, n=29), both groups were treated with transdermal fentanyl initially (25 μg/ h), a higher dose ( 50 μg/ h) was given only when the pain of patients was not cont rolled well. Clodine (20 mg,bid,po) was given beside fentanyl patch in C group. The analgesic effect, and the side effects and incidence of PHN were observed.［Results］Compared with F group, highly effective，total effective rate of C group is significantly higher (P<0.05); complications and incidence of PHN significantly decreased in C group.［Conclusions］Transdermal fentanyl combined with Clodine could provide excellent pain relief for the patients with acute herpes zoster and decrease the incidence of complications and PHN.