卒中后抑郁的生物学指标探讨

Study of biological marker in poststroke depression

关键词:  PSD  DST  血清皮质醇

Key words:  poststroke depression  dexamethasone suppression test  serum cortisol

摘要:

［目的］探讨急性卒中后抑郁（poststroke depression ,PSD）临床生物学的诊断指标。［方法］通过放射免疫方法测定比较血清皮质醇水平。［结果］（1）基础血清皮质醇浓度在急性单纯性卒中组及急性PSD组均明显增高，二组之间在增高比率上差异无显著性意义（P>0.05）。（2）地塞米松抑制试验 （dexamethasone suppression test ，DST）在PSD组敏感性为68%，特异性为84%，其中轻度PSD组DST敏感性为81%，重度PSD组DST敏感性为53%，均显著高于急性单纯性卒中组DST的敏感性（P<0.01）。［结论］DST可做为急性PSD的实验室生物学诊断检测指标，尤其对轻度急性PSD,其敏感性、特异性高。

Abstract:

［Objective］To explore biological marker for the diagnosis of poststroke depression.［Methods］Cortisol was analyzed with a radionimmunoassay.［Results］（1）Baseline serum cortisol was obviously higher.（2）The sensivity of the dexamethasone suppression test was 68% and the specificity 84%,especially in minor poststroke depression the sensivity was 81%.［Conclusions］These data suggested that dexamethasone suppression test may be used as a supplementary marker in the diagnosis of acute poststroke depression.