类风湿关节炎病人血清中催乳素水平及与IL-6的关系

Measurement of prolactin from sera in patients with rheumatoid arthritis

关键词:  类风湿关节炎  催乳素  白细胞介素6

Key words:  rheumatoid arthritis  prolactin  interleukin-6

摘要:

［目的］探讨催乳素在类风湿关节炎（rheumatoid arthritis, RA）发病中的作用。［方法］放射免疫分析法检测RA病人血清中催乳素及白细胞介素6（IL-6）的水平。［结果］RA组与对照组血清中催乳素水平分别为(9.9±3.0) g/L与(8.5±2.4) g/L(P<0.05)；IL-6的水平分别为(27.8±7.5) pg/mL与(15.6±3.2) pg/mL (P<0.01)。催乳素水平与IL-6呈正相关关系(r=0.52；P<0.01)。［结论］催乳素可能是导致RA发病的一个因素，且与IL-6可能存在着相互调节的作用。

Abstract:

［Objective］To study the role of prolactin on pathogenesis of rheumatoid arthritis (RA) and the relation between prolactin and interleukin-6 (IL-6).［Methods］Prolactin and IL-6 from RA patients group and normal persons controls group were determined by radioimmunoassay.［Results］In RA patients and controls, the levels of prolactin were 9.9±3.0 g/L and 8.5±2.4 g/L(P<0.05). The levels of IL-6 were 27.8±7.5 pg/mL.and 15.6±3.2 pg/mL (P<0.01). There was positive correlation between prolactin and IL-6 (r=0.52；P<0.01).［Conclusions］The prolactin palys a role in the pathogenesis of RA and assocaites with disease activity.