| 摘要: |
| ［目的］探讨基质金属蛋白酶-9（MMP-9）和CD147在口腔鳞癌侵袭转移过程中的作用和二者的相互关系。［方法］应用免疫组化方法检测48例口腔鳞癌和10例正常口腔黏膜组织的MMP-9、CD147蛋白的表达。［结果］口腔鳞癌组织和对照组织中MMP-9表达阳性率分别为87.5%和10.0％；CD147表达阳性率分别为 89.6%和20.0％。有、无淋巴结转移组织中，MMP-9表达阳性率分别为100.0%和64.7%；CD147表达阳性率分别100.0%和70.6% 。二者在各组间表达差异有显著性意义（P<0.01）。［结论］MMP-9和CD147参与口腔鳞癌的侵袭转移。 |
| 关键词: MMP-9 CD147 鳞癌 转移 |
| DOI：10.11724/jdmu.2007.03.05 |
| 分类号:R739 |
| 基金项目: |
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| Function of MMP-9 and CD147 expression in invasion and metastasis of oral squamous cell carcinomas |
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QIU Wei1, SUN Lei2, YU Xiao2, DU Qi-tao1
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1.Dalian Stomatological Hospital, Dalian 116021, China;2.Sino-Japan Clinical Pathology Center, Dalian Medical University,Dalian 116027, China
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| Abstract: |
| ［Objective］This study explored the function and correlationship of MMP-9 and CD147 in the invasion and metastasis of oral squamous cell carcinomas (OSCC). ［Methods］The expressions of MMP-9 and CD147 were detected in 48 cases specimens OSCC group and 10 cases of normal mucosa control group embedded in paraffine by immunohistochemical method.［Results］The positive expression rates of MMP-9 were 87.5% in OSCC group and 10.0%in control group(P<0.01). The rates of CD147 were 89.6% and 20.0% respectively(P<0.01). In the group with metastasis and without the positive expression rates of MMP-9 were 100.0% and 64.7%(P<0.01). The positive expression rates of CD147 were 100.0% and 70.6% respectively(P<0.01).［Conclusions］MMP-9 and CD147 play an important role in the invasion and metastasis. |
| Key words: MMP-9 CD147 oral squmous cell carcimoma metastasis |
