血清GPDA测定对原发性肝癌和肝血管瘤的鉴别诊断

Diagnostic serum GPDA detection in primary hepatocelluar carcinoma and hepatic hemangioma

关键词:  GPDA  原发性肝癌  肝血管瘤

Key words:  GPDA  primary hepatocelluar carcinoma  hepatic hemangioma.

摘要:

［目的］探讨测定血清甘氨酰脯氨酸二肽氨基肽酶(GPDA)对鉴别诊断原发性肝癌和肝血管瘤的意义。［方法］ 收集2006年5月～11月于大连医科大学第一临床学院就诊的原发性肝癌病人和肝血管瘤病人的血清标本作为实验组，收集于大连医科大学第一临床学院体检的健康人血清标本作为对照组。应用日立7170S全自动生化分析仪测定各组血清GPDA值。采用 t 检验对结果进行分析。［结果］原发性肝癌患者GPDA活性为（156±45）U/L。肝血管瘤患者血清GPDA活性为（77±16）U/L。对照组血清GPDA活性为（84±22）U/L。原发性肝癌患者血清GPDA与肝血管瘤患者血清GPDA之间的差异有统计学意义（P<0.05）；肝血管瘤患者血清GPDA与对照组血清GPDA之间的差异无统计学意义（P>0.05）。［结论］测定血清GPDA有助于鉴别原发性肝癌与肝血管瘤。

Abstract:

［Objective］To evaluate the method of measuring serum GPDA level in distinguishing primary hepatocelluar carcinoma from hepatic hemangioma.［Methods］The sera of the primary hepatocelluar carcinoma patients and hepatic hemangioma patients that were certified in May to Novermber of 2006 were collected as experiment groups. The sera of healthy persons who came to our hospital for physical examination were collected as control group. Serum GPDA of each group was measured with 7170s automatic analyzer.Test was adopted to analyze data.［Results］The activity of primary hepatocelluar carcinoma patients was(156±45)U/L. The activity of GPDA of hepatic hemangioma patients was(77±16) U/L.The activity of control group was(84±22) U/L.There was statistic difference between primary hepatocelluar carcinoma patients group and hepatic hemangioma patients group. There was not statistic difference between hepatic hemangioma patients group and control group.［Conclusions］Measuring serum GPDA level could help to differentiate primary hepatocelluar carcinoma from hepatic hemangioma to some extent.