地塞米松对阿曲库铵神经阻滞效应的影响

Effects of dexamethasone on neuromuscular blocking efficiency of atracurium

关键词:  地塞米松  阿曲库铵  神经阻滞效应

Key words:  dexamethasone  atracurium  neuromuscular blocking efficiency

摘要:

［目的］观察地塞米松对阿曲库铵神经肌肉阻滞效应的影响。［方法］ 选择择期甲状腺肿物切除术病人80例，随机分成两组：地塞米松组，麻醉诱导前静脉注射地塞米松10 mg，10 min后按顺序静脉注射咪唑安定0.1 mg/kg、芬太尼 4 μg/kg、丙泊酚2 mg/kg、阿曲库铵0.6 mg/kg；对照组，麻醉诱导前给予同等剂量生理盐水，之后给予相同剂量麻醉诱导药物。观测两组患者拇内收肌群TOF，记录T1消失的时间及第1次T0F恢复时T1出现的时间。［结果］ 地塞米松组阿曲库铵起效时间为(289.0±19.7) s，比对照组(226.4±11.2) s明显延长，恢复时间为(13.7±0.5) min，比对照组(20.8±3.2) min明显缩短(P<0.05)。［结论］地塞米松可减弱阿曲库铵对全麻病人的神经肌肉阻滞效应。

Abstract:

［Objective］To observe the effects of dexamethasone on neuromuscular blocking efficiency of atracurium. ［Methods］Eighty patients with ASA I-II who underwent thyroid surgery were randomly divided into two groups : dexamethasone group, the patients received intravenously 10 mg dexamethasone before anesthesia induction, then were given midazolam 0.1 mg/kg, fentanyl 4 μg/kg, propofol 2 mg/kg, atracurium 0.6 mg/kg；control group, the patients were given same volume saline before anesthesia induction，then anesthesia induction were taken with same drugs and dosage. Train-of-four（TOF）were applied to ulnar nerve-adductor pollicis，time of T1 disappeared and recovered at first time was recorded.［Results］Time of onset of atracurium of Dexamethasone group (289.0±19.7)s prolonged significantly than that of control group (226.4±11.2)s (P<0.05); and recovery time of atracurium of Dexamethasone group (13.7±0.5)min was shorter significantly than that of control group (20.8±3.2)min (P<0.05). ［Conclusion］Dexamethasone may attenuate the efficiency of neuromascular blockage of atracurium.